Cell 36: 163-170.D. Takai, S. Hooper, S. Blackwood, R. Gandhi, and T. de Lange (2010). Cell. Telomeres and senescence: ending the debate. Jan 5. Lue, R.R. I. Schmutz, L. Timashev, W. Xie, D.J. Flavell, F.G. Grosveld (1984) ?-globin gene inactivation by DNA translocation in ?/?-thalassemia. D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. Cell Reports 13: 1633- 1646. TRF2 protects human telomeres from end-to-end fusions. Cold Spring Harb. M. Zimmermann, and T. de Lange (2013) 53BP1: pro choice in DNA repair. Cell 141: 81-93. Biol. B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Bryan (2015) ATM and ATR signaling regulate the recruitment of telomerase to telomeres. ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. 20: 5532-5540. Chromosoma 120: 151-157. de Lange (2009) Human telomerase caught in the act. Science 270: 1663-1667. As part of her undergraduate training, she worked on globin gene expression with Richard Flavell at the NIMR in Mill Hill before joining Piet Borst in 1981 … Copyright © 2004–2020 The Rockefeller University. Hueting, T. de Lange, D.W. Tempest (1979) Energy requirement for maintenance of the transmembrane potassium gradient in Klebsiella aerogenes NCTC 418: a continuous culture study. 18: 5735-5744.T. Meeker. Nature Cell Biol. Control of human telomere length by TRF1 and TRF2. Bianchi and T. de Lange (1999) Ku binds telomeric DNA in vitro. T. Kibe, G.A. Biol. 28: 153-166. 20: 1659-1668. A. Sfeir, S. Kabir, M. van Overbeek, G.B. Cell, 39:839-850. A. Sfeir, S.T. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. T. de Lange (2001) Telomere capping: one strand fits all. Biol, 27: 585-610. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. TRF1 promotes parallel pairing of telomeric DNA in vitro. Kioussis, D. Vanin, T. de Lange, R.A.F. Nature Rev. Ann Rev Genetics 42:301-334. Biol. Annu. 15: 1579-1586. The Rockefeller University | 1230 York Avenue, New York, NY 10065 | 212-327-8000 Homologous recombination generates t-loop sized deletions at human telomeres. Targeted deletion reveals an essential function for the telomere length regulator Trf1. J. Biol. Mol. It was a lot of fun, so that made me stay in science. Cell 34: 891-900.L.H.T. Science 282: 1484-1488.Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Genet. Regulation of telomerase by telomeric proteins. K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Varmus (1990) Structure and variability of human chromosome ends. Myers, D.R. van der Ploeg, P. Borst, M.C. 24: 2667-2678. Chem. D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell Dev. Cell Sci. Smogorzewska and T. de Lange (2004) Regulation of telomerase by telomeric proteins. T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. 24: 2019-2030. de Lange, T. (2010) Telomere Biology and DNA repair: Enemies with benefits. Cell.  Shelterin subunits are not the only proteins that associate with telomeres but they differ from other proteins by meeting the criteria of not accumulating in areas beside chromosome ends, their function is limited to telomeres, and they are present at telomeres throughout the cell cycle. T. de Lange (2005) Mammalian telomeres. D. Frescas and T. de Lange (2014) A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. 5: 323-329. J. Biol. de Lange and R. DePinho (1999) Unlimited mileage from telomerase? Biochem. Cell 14: 5060-5068. Veeneman, J.C. van Boom (1982) RNA splicing is required to make the messenger RNA for a Variant Surface Glycoprotein in trypanosomes. Jacobs and T. de Lange (2005) p16INK4as a second effector of the telomere damage response. 285: 1457-1467. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains.  This architectural change allows for TRF2 to sequester the ends of telomeres, which function to safeguard telomeres by covering overhanging single strands of DNA. Mol. Science 279: 334-335.X. Stone, T. de Lange, G. Ramsay, E. Jacobovits, J.M. T. de Lange (2018) Shelterin-mediated telomere protection. McMillan press.  In her research, she proposed that TRF1 inhibits the action of telomerase. 190: 1-10.T. Biol.16: 1295-1302. Frasch, J.D. Broccoli, L.A. Godley, L.A. Donehower, H.E. D. Hockemeyer, A. J. Sfeir, J.W. Genet. M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. S. Hanaoka, A. Nagadoi, S. Yoshimura, S. Aimoto, B. Li, T. de Lange, Y. Nishimura (2001) NMR structure of the hRap1 Myb motif reveals a canonical three helix bundle lacking the positive surface charge typical of Myb DNA binding domains. A. Smogorzewska and T. de Lange (2002). Acad. Chem. J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instability. TRF1 binds a bipartite telomeric site with extreme spatial flexibility. Structure and variability of human chromosome ends. H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases.