2: 2017: The following articles are merged in Scholar.  While working at UCSF, de Lange continued her work on telomeres. Cell 155, 345–356 (2013). De Lange is the recipient of several awards including the 2001 Paul Marks Prize for Cancer Research, the 2008 Massachusetts General Hospital Cancer Center Prize, the 2010 AACR Clowes Memorial Award, the 2011 Vanderbilt Prize in Biomedical Science, the 2011 Vilcek Prize in Biomedical Science, the 2013 Breakthrough Prize in Life Sciences, the 2014 Gairdner International Award, and the 2017 Rosenstiel Award. The lab also studies DNA double-strand break repair with emphasis on the function of two critical DNA repair proteins, BRCA1 and 53BP1. 10: 518-527. 75th CSH Symp.  She also earned her Ph.D. from the University of Amsterdam while working at the Netherlands Cancer Institute. They found that shelterin recruits CST/polα/primase to telomeres to mitigate over-resection and prevent excessive telomere shortening. Varmus (1990) Structure and variability of human chromosome ends. Titia de Lange 09/14 page 4 BIBLIOGRAPHY (Reviews, book chapters, and commentaries in italics.) Since 1990 she has had a faculty position at the Rockefeller University. The lab studies telomeres, protective elements at the ends of chromosomes that are critical for genome integrity and shorten with cell division. Their combined citations are counted only for the first article.  de Lange spoke highly of the lab saying "That was where I first saw how science is really done. , In 2000 she became correspondent of the Royal Netherlands Academy of Arts and Sciences. Retrieved from, L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. , Titia de Lange originally wanted to study chemistry after finishing high school in the Netherlands but the lack of women in chemistry among students and teachers alike convinced her to study biology with a biochemistry track instead. Journal of Organometallic Chemistry 840, 11-22, 2017. Shelterin represses six distinct DNA damage response pathways. John Maciejowski, a postdoctoral fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics, has received the 2016 Regeneron Prize for Creative Innovation. The award, given by Regeneron Pharmaceuticals, Inc., recognizes innovative young scientists based on proposals they submit that have the potential to drive biomedical research forward. The lab identified a six-subunit protein complex, which they named shelterin, that specifically binds to telomeres. Biol.,75: 167-177. Nature 385: 740-744. Using genetic approaches, de Lange and her colleagues determined the fate of telomeres lacking one or more of the six shelterin subunits. Cell 163, 1641–1654 (2015). Retrieved from, Last edited on 29 November 2020, at 22:11, Royal Netherlands Academy of Arts and Sciences, Telomeric-repeat binding factor protein 1 (TRF1), "The Rockefeller University De Lange lab", "Titia de Lange receives 2011 Vilcek Prize in Biomedical Science | Newswire", "Cori Bargmann, Titia de Lange win inaugural Breakthrough Prizes worth $3 million", "Titia de Lange: The Complex Puzzle of Chromosome Ends - Rita Allen Foundation", "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Titia de Lange", https://dx.doi.org/10.1016/j.cell.2004.10.011, https://dx.doi.org/10.1101/sqb.2010.75.017, https://dx.doi.org/10.1016/S0092-8674(00)80760-6, https://dx.doi.org/10.1016/S0092-8674(00)80932-0, "Titia de Lange - 2013 Breakthrough Price in Life Sciences", https://en.wikipedia.org/w/index.php?title=Titia_de_Lange&oldid=991406006, Creative Commons Attribution-ShareAlike License, This page was last edited on 29 November 2020, at 22:11. 53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair. (2004). A third area of interest is to understand how cells repair double-strand breaks. Cell 92: 401-413. Leon Hess Professor American Cancer Society Professor Head of Laboratory of Cell Biology and Genetics Director, Anderson Center for Cancer Research The Rockefeller University 1230 York Avenue New York NY 10065 Phone: (212) 327 7464 Fax: (212) 327 7147 e-mail: [email protected] Genes and Development 19: 2100-2110. E pub. Their combined citations are counted only for the first article.