robert sapolsky google scholar

The review will delineate challenges, limitations and opportunities for successful gene therapy.There are sizeable gains in knowledge about functioning of the fear system. Furthermore, delivery of the vector even after onset of the seizure is protective, suggesting that HSV-mediated gene transfer for neuroprotection need not be carried out in anticipation of neurologic crises. View details for Web of Science ID A1996WP10200036. Brooke, S. M., Howard, S. A., Sapolsky, R. M. Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studies. Moreover, although it has been confirmed that mild hypothermia is clinically feasible for acute focal stroke treatment, no definite beneficial effect has been reported yet. Mn SOD activity was unaffected by treatment. As a positive control, the same vector significantly protected against the excitotoxin kainic acid. View details for Web of Science ID 000175059800007. Dinkel, K., Macpherson, A., Sapolsky, R. M. Gene therapy and hypothermia for stroke treatment. In examining animals ranging in age from juvenile status to old age, we observed a robust decline in DS concentrations with age. View details for Web of Science ID 000167951300038. Furthermore, NAP partially protected against kainic acid excitotoxicity. Finally, we observed that the synthetic GC prednisone had similarly exacerbating effects on gp120. Save time and never re-search. Kelly, S., Zhang, Z. J., Zhao, H., Xu, L. J., Giffard, R. G., Sapolsky, R. M., Yenari, M. A., Steinberg, G. K. Disruptive effects of glucocorticoids on glutathione peroxidase biochemistry in hippocampal cultures. A survey of sexually mature baboons at Lake Manyara National Park in 2006 carried out as part of this study indicated that roughly ten percent displayed T. pallidum-associated lesions severe enough to cause major structural damage to the genitalia. Brain and liver glycogen and glucose and plasma glucose levels were measured. Thus, cells were unlikely to be able to detoxify the excess hydrogen peroxide produced as a result of the CuZnSOD overexpression. We now report that exposure of transgenic mice to an "enriched environment" results in pronounced reductions in cerebral Abeta levels and amyloid deposits, compared to animals raised under "standard housing" conditions. View details for DOI 10.1371/journal.pone.0109803, View details for Web of Science ID 000343941200074, View details for PubMedCentralID PMC4192591. One solution that has evolved, primarily in the hippocampus within the nervous system, involves the presence of two different types of receptors for GCs within the same cells; so long as the two receptors have very different affinities and mediate opposing effects on some cellular endpoint, an inverse U will emerge. New articles related to this author's research. Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J., Cai, L., Cedergreen, N., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., Cook, R. R., Diamond, D. M., Doolittle, D. J., Dorato, M. A., Duke, S. O., Feinendegen, L., Gardner, D. E., Hart, R. W., Hastings, K. L., Hayes, A. W., Hoffmann, G. R., Ives, J. The "behavioral manipulation" hypothesis postulates that a parasite will specifically manipulate host behaviors essential for enhancing its own transmission. We show that though p35 and crmA rescued neurons from toxicity, they did so under conditions of negligible caspase activation and morphological apoptosis. In both cases, pretreatment with high glucose abolished this CORT-mediated synergy. The mTOR inhibitor rapamycin blocked the protective effects of both cAkt1 and cAkt3. View details for DOI 10.1111/j.1460-9568.2004.03819.x, View details for Web of Science ID 000225686000003. This raises the possibility that preventing such neuron death via gene therapy can secondarily protect neighboring neurons that, themselves, do not express a protective transgene. Glucose reduction, by the approximate magnitude by which corticosterone inhibits glucose transport, mimicked the corticosterone effect on the peak magnitude of the calcium response to kainic acid. View details for DOI 10.1016/j.cell.2005.01.015, View details for Web of Science ID 000227771400015, View details for Web of Science ID 000227523800492. All three secretagogs are thus apparently involved in the corticosterone response to frustration. We investigate these conflicting suggestions in the present report. Identical 24-h CORT treatment caused a 13% reduction in glucose uptake in astrocytes and a 38% reduction in glycogen content, without affecting the level of intracellular glucose. Taken together, these findings demonstrate that neurofibrillary tangle-like alterations in tau, and spectrin breakdown, can be induced by excitatory amino acids and exacerbated by GCs in vivo. View details for Web of Science ID 000180087300006. Receptor concentrations in the dentate gyrus increased dramatically between Days 9 and 15, while the changes during this period in the pyramidal layers of Ammon's horn seemed to reflect both structural changes in these regions as well as increases in receptor concentrations. These findings suggest that Bcl-2 can have antioxidant actions that may nonetheless not be central to its protective effects, can protect against an ROS generator without targeting steps specific to oxidative biochemistry, and can protect in the absence of ROS generation. We discuss (a) the trafficking of glutamate and calcium during insults; (b) oxygen radical generation and programmed cell death occurring during insults; (c) neuronal defenses against insults; (d) the role of energy availability in modulating the extent of neuron loss following such insults. View details for DOI 10.1016/j.bippsych.2004.04.012, View details for Web of Science ID 000222878800001. We compared the subset of monkeys who were most DEX responsive (post-DEX cortisol values of 3.1 +/- 0.5 micrograms/dl) versus a DEX-resistant subset (cortisol values of 9.2 +/- 2.0 micrograms/dl); we found two features that distinguished these groups: (a) DEX-resistant monkeys had significantly fewer available glucocorticoid receptor (GR) binding sites in the hippocampus; they did not differ in numbers of mineralocorticoid receptor (MR) sites in the hippocampus, nor in numbers for either receptor in the cortex or hypothalamus as a whole. Using microdialysis, we have previously observed that GCs augment the extracellular accumulation of glutamate and aspartate in the hippocampus following kainic acid-induced seizures. II. Hypothermia is protective in stroke models, but findings from permanent occlusion models are conflicting. Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status.

Skyrim Light Armor Perk Id, 2013 Lincoln Mkz For Sale, Guitar Pedal Not Passing Signal, Corporation Tax Courses Uk, Jerusalem District Zip Code, Skaven Army Composition Age Of Sigmar, Online Yoga Teacher Workshops, All About Ph, Walrus Audio Julia, Grandkids Birthstone Bracelet,

Leave a Reply

Your email address will not be published. Required fields are marked *